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Scientific Publications

**NEW** Long-Term Stability of Primary Rat Hepatocytes in Micropatterned Co-Cultures.  Okechukwu Ukairo, Chitra Kanchagar, Amanda Moore, Julianne Shi, Jeannemarie Gaffney, Simon Aoyama, Kelly Rose, Stacy Krzyzewski, Jack McGeehan, Melvin E. Andersen, Salman R. Khetani, Edward L. LeCluyse.   Journal of Biochemical and Molecular Toxicology, first published online January 11, 2013.

**NEW** The Use of Micropatterned Co-Cultures to Detect Compounds that Cause Drug induced Liver Injury in Humans.  Salman R. Khetani, Chitra Kanchagar, Okechukwu Ukairo, Stacy Krzyzewski, Amanda Moore, Julianne Shi, Simon Aoyama, Michael Aleo and Yvonne Will.   Toxicological Sciences, first published online November 14, 2012.

Assessment of a Micropatterned Hepatocyte Co-Culture System to Generate Major Human Excretory and Circulating Drug Metabolites.   Wendy WeiWei Wang, Salman R. Khetani, Stacy Krzyzewski, David Duignan and R. Scott Obach.  Drug Metabolism and Disposition, Vol. 38(10), p 1900-1905 (2010).

Persistent Hepatitis C Virus Infection in Microscale Primary Human Hepatocyte Cultures.  Ploss A, Khetani SR, Jones CT, Syder AJ, Trehan K, Gaysinskaya VA, Mu K, Ritola K, Rice CM, Bhatia SN.   Proc Natl Acad Sci U S A, Vol. 107(7), p 3141-3145 (2010).

Real-Time Imaging of Hepatitis C Virus Infection Using a Fluorescent Cell-Based Reporter System.  Jones CT, Catanese MT, Law LM, Khetani SR, Syder AJ, Ploss A, Oh TS, Schoggins JW, MacDonald MR, Bhatia SN, Rice CM.   Nature Biotechnology, Vol. 28(2), p 167-171 (2010).

Microscale Culture of Human Liver Cells for Drug Development.  Salman R. Khetani and Sangeeta N. Bhatia.   Nature Biotechnology, Vol. 26, p 120-126 (2008).

Combinatorial Signaling Microenvironments for Studying Stem Cell Fate.  Christopher J. Flaim, Dayu Teng, Shu Chien, and Sangeeta N. Bhatia.  Stem Cells and Development, Vol. 17, p 29-39 (2008).

Micromechanical Control of Cell-Cell Interactions.  Elliot E. Hui and Sangeeta N. Bhatia.   Proc Natl Acad Sci U S A, Vol. 104, No. 14, p 5722-5726 (2007).

Engineering Tissues for In Vitro Applications.  Salman R. Khetani and Sangeeta N. Bhatia.   Current Opinion in Biotechnology, Vol. 17, p 524-531 (2006).

An Extracellular Matrix Microarray for Probing Cellular Differentiation.  Chistopher J. Flaim, Shu Chien and Sangeeta N. Bhatia.   Nature Methods. Vol 2, No. 2, p 119-125 (2005).

Photo- and Electropatterning of Hydrogel-Encapsulated Living Cell Arrays.  Dirk R. Albrecht, Valerie Liu Tsang, Robert L. Sah and Sangeeta N. Bhatia.   Lab on a Chip, Vol. 5, p 111-118 (2005).

In vitro Zonation and Toxicity in a Hepatocyte Bioreactor.  Jared W. Allen, Salman R. Khetani and Sangeeta N. Bhatia.   Toxicological Sciences, Vol. 84, p 110-119 (2005).

Controlling Cell Interactions by Micropatterning in Co-Cultures: Hepatocytes and 3T3 Fibroblasts.  Sangeeta N. Bhatia, Martin L. Yarmush, and Mehmet Toner.   Journal of Biomedical Materials Research, Vol. 34, 189-199 (1997).

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