Evaluation of Tolvaptan-Induced Stress Response Pathways in HepatoPac Using a Combined Experimental Approach of Toxicogenomics, Cellular Imaging, and Exosome Analysis.
Presenter: Dr. Merrie Mosedale, UNC Chapel Hill
Date/Time: Wednesday, March 15th, 3:00 pm to 4:00 pm.
Location: Room 337
Description: This talk will describe using a combined experimental approach of gene-expression profiling, high-content imaging, and exosome analysis in micropatterned cocultures of primary human hepatocytes and 3T3-J2 murine fibroblasts to provide insight into the cellular mechanisms contributing to idiosyncratic drug-induced liver injury associated with the vasopressin receptor antagonist tolvaptan
This session is an Exhibitor-Hosted Session. Although not an official part of the SOT Annual Meeting scientific program, its presentation is permitted by the Society.
Development of a Novel Micropatterned Co-Culture Model with Primary Dog Hepatocytes to Aid in Accurate Prediction of DILI Risk - Poster Board Number: P433. Presented by Ascendance Biotech
Assessment of Drug Induced Liver Injury and Metabolite Formation in Engineered Human Micropatterned Hepatocyte Co-culture - Poster Board Number: P136. Wednesday, March 15th 1:15 pm to 4:30 pm. Presented by UCB Pharma
Validation of a High-Content Imaging Assay for Steatosis in a Micropatterned Human Hepatocyte Co-culture Model - Poster Board Number: P503. Thursday, March 16th, 8:30 am to 11:45 am. Presented by ScitoVation