Rat HepatoPac® kits are an ideal way to conduct all your DMPK, Predictive Toxicology & Mechanistic Toxicology applications. These kits come in a ready-to-use format of Rat HepatoPac; co-cultures micropatterned on industry-standard 24- and 96-well plates for streamlined, higher throughput in vitro assays. A variety of rat kits are available to cover all your application and size needs, and contain everything you need to conduct your assays. Begin dosing as early as 3 days after receiving the kit!
Satisfaction Guaranteed! Every kit is backed by Hepregen's performance guarantee and professional customer scientific support. If you are unable to produce desired results in your lab, Hepregen's scientists will run your compounds through our in-house pipeline.
Rat HepatoPac in vitro co-cultures remain viable and highly functional for 4 weeks. These co-cultures secrete albumin, synthesize urea, display functional bile canaliculi, and metabolize compounds using active Phase I and Phase II drug metabolism enzymes.
HepatoPac kits can be used for any assay that can be run using sandwich, monoculture plates or suspension cultures. Due to the extended in vitro functionality of HepatoPac co-cultures, Hepregen kits enable studies such as low turnover clearance or chronic toxicity studies that could not otherwise be performed. Rat HepatoPac kits are application-specific, containing optimized media and plate layouts.
- Toxicology Screening
- DMPK applications - MetID, Metabolic Stability, Induction, Transporter
Don't see your application? Hepregen scientists are available to discuss your application needs and recommend the appropriate kit, or develop a custom solution.
All kits are provided with pre-patterned primary rat hepatocyte/stromal cell co-cultures. Primary hepatocytes and stromal cells are patterned on Day 0, cultured at Hepregen and shipped to clients on Day 5 of culture. Plates are delivered within 24 to 48 hours of shipping. Cells are ready for dosing on Day 8 of culture (1 to 2 days after receiving the plates). HepatoPac co-cultures remain functional for up to 4 weeks in vitro, providing users with schedule flexibility. We take great pride in the reliability of co-culture manufacturing and their stability during shipping. Learn more about Kit Quality.
Type Title Publication Bioactivation and Toxicity of Acetaminophen in a Rat Hepatocyte Micropatterned Coculture System. Journal of Biochemical and Molecular Toxicology. Early Release Epub, August 5, 2013. Publication Long-Term Stability of Primary Rat Hepatocytes in Micropatterned Co-Cultures. Journal of Biochemical and Molecular Toxicology, first published online January 11, 2013. Publication Use of Micropatterned Cocultures to Detect Compounds that Cause Drug Induced Liver Injury in Humans. Toxicological Sciences, Vol. 132, Issue 1, March 2013, Pages 107-117. Poster Enhancement of Proliferation in a Novel Rat Hepatocyte Co-Culture Model after Mitogenic Stimulation.