We take great pride in the reliability of our co-culture kit manufacturing and quality. All kits contain industry-standard 24- or 96-well microplates that contain pre-patterned HepatoPac™ co-cultures. HepatoPac™ co-cultures are extensively characterized for each donor and model system. Specific information for individual donor/lots is available in the specification sheet section of our web resource center.
Reproducibility of HepatoPac
HepatoPac co-cultures derived from a single donor show a high level of reproducibility. Performance in a variety of toxicity assays was evaluated and found to be nearly identical. Figure 1 summarizes the results of ATP examination (CellTiter-Glo®) following dosing with a variety of compounds.
Other endpoints tested:
- Urea synthesis
- Albumin secretion
HepatoPac kits are shipped on Day 5 following co-culture plating. Hepregen conducted extensive shipping studies on all co-cultures to ensure viability throughout the shipping process. Test results summarizing this data are summarized below.
Shipping Study (US to Europe)