In this Newsletter:
Utility of Micropatterned Hepatocyte Co-Cultures for Drug Toxicity Studies
Thursday, November 21, 2013
11:00am - 12:00 EDT
Salman R. Khetani, Ph.D., Colorado State
Co-founder of Hepregen and Co-inventor of
Micropatterned co-cultures (MPCC) were developed as a more stable and long-term model of the liver, containing primary hepatocytes from animal (rat, mouse, dog, monkey) and human species arranged in empirically optimized clusters and surrounded by 3T3-J2 murine embryonic fibroblasts.
In this presentation, Dr. Khetani will discuss:
- Engineering of micropatterned co-cultures (MPCC)
- Use of MPCC in toxicity studies
- Acetaminophen bio-activation case study
- Applications in Hepatitis C and Type 2 Diabetes
- MPCC model using iPSC-derived human hepatocytes
Expanded Product Line
- Monkey HepatoPac™ Co-Cultures
- Maintenance Media
- Application-specific Media and additives
- Instructions for culture maintenance and application-specific protocols
- On-site customer training included
Hepregen's ready-to-use HepatoPac® MetID kits are now available using monkey donor hepatocytes. Each kit contains everything you need to perform your MetID assays. Begin dosing as early as 3 days after receiving the kit. Every kit is backed by Hepregen's performance guarantee and professional customer scientific support. If you are unable to produce the desired results in your lab, Hepregen's scientists will run your compounds through our inhouse pipeline.
HepatoPac® MetID kits are available in four other donor formats: Human Triple Donor, Rat / Human Multi-species, Human and Rat.
Annual User Group MTG
We would like to thank all the participants of Hepregen's Second Annual User Group Meeting. A special thanks to all our presenters for sharing the exceptional data they have generated using Hepregen's HepatoPac® Micro-liver technology.
The Hamner Institute
David Peters, PhD
Ragu Ramanathan, PhD
Kenneth Brouwer, PhD, RPh
Qualyst Transporter Solutions
Julius Enoru, PhD & William DeMaio, PhD
Yvonne Schaus, PhD