HepatoPac™ Highlights - Volume 3, February 2013

Epregen Newsletter

HepatoPac™ Highlights


In this Newsletter:

New Publications

New Publications

Long-Term Stability of Primary Rat Hepatocytes in Micropatterned Cocultures.

Ukairo O, Kanchagar C, Moore A, Shi J, Gaffney J, Aoyama S,  Rose K, Krzyzewski S, McGeehan J, Andersen ME, Khetani SR, Lecluyse EL.

J Biochem Mol Toxicol. 2013 Jan 11. (Epub)

Abstract: Primary hepatocytes display functional and structural instability in standard monoculture systems. We have previously developed a model in which primary hepatocytes are organized in domains of empirically optimized dimensions and surrounded by murine embryonic fibroblasts (HepatoPac™) ... Read More

 

New Publications

The Use of Micropatterned Co-cultures to Detect Compounds that Cause Drug induced Liver Injury in Humans.

Khetani SR, Kanchagar C, Ukairo O, Krzyzewski S, Moore A, Shi J, Aoyama S, Aleo M, Will Y.

Toxicol Sci. (2013) 132(1): 107-117. First publisged online November 14,2012

Abstract: Since drug induced liver injury (DILI) remains a major reason for late stage drug attrition, predictive assays are needed that can be deployed throughout the drug discovery process Clinical DILI can be predicted with a sensitivity of ~50% and a false positive rate of ~5% using 24 hour cultures of primary sandwich cultured human hepatocytes ... Read More

Upcoming Scientific Presentations

Upcoming Scientific Presentations

Workshop at Society of Toxicology Conference
52nd Annual Meeting & ToxExpo™

March 11-14, 2013
San Antonio, TX
Booth #521

Exhibitor Workshop High Content Imaging,
In-Vitro Predictive Toxicology Evaluation of the HepatoPacâ„¢ Model.

Joe Trask - Head of Cellular Imaging Core, Hamner Institute for Health Sciences
Date: Tuesday, March 12, 2013
Time: 2:45 - 3:45pm
Location: Room 7C

A Micro-Patterned Culture with Primary Hepatocytes and Kupffer Macrophages for Studying Inflammation- Drug Interactions
Presented: Thursday, March 14, 2013 - 8:30am to 12:00pm

User Group Meetings

User Group Meetings

We would like to thank our presenters and attendees for making the 1st Hepregen User Group Meeting a success. Due to the positive feedback we have received, we anticipate making User Group Meetings a regular event. Stay tuned for future announcements.

 

Coming Soon

 

Coming Soon

Coming soon HepatoPac™ Plates
Bring the most validated micro-liver technology to your lab.



 

Meeting up with Hegregen

Society of Toxicology 52nd Annual Meeting & ToxExpo™
March 11-14, 2013
San Antonio, TX



Exhibitor Workshop
High Content Imaging, In Vitro Predictive Toxicology Evaluation of the HepatoPacâ„¢ Model Presented by Joe Trask, Hamner Inst. Tuesday, March 12, 2013 2:45 - 3:45pm