Hepregen User Group Meetings

2016 New England User Group Meeting - April 21, 2016

Royal_Sonesta_Image

Royal Sonesta, Boston
April 21, 2016
Cambridge, MA

Dr. Eric Tien - Biogen
Title: In vitro Testing for Prediction of Liver Toxicity in the Rat

Dr. Petra Koza-Taylor - Pfizer
Title: Utilizing RNA-Seq to Increase the Sensitivity of the HepatoPac® Platform in Identifying 

Dr. Joe Trask - ScitoVation LLC
Title: High Content Imaging of Hepatocytes in a Micropatterned Coculture System

Dr. Edward LeCluyse - LifeNet Health
Title: Nuclear-Receptor-Mediated Enzyme Induction in the Human HepatoPac® Model System Following Treatment with Hepatotoxic Compounds

Dr. Ryan Takahashi - Genentech
Title: Assessing rates of human P450 turnover by direct protein measurement with HepatoPac®

Dr. Keith Goodman - SCIEX
Title: Discovery Simplified: A Primer on the Advances of Metabolite ID Using SWATH® Acquisition

David Larocca, Ph.D. - ReCyte
Title: Co-culture Model of Angiogenesis using Novel Pericyte-like Cells derived from Human Pluripotent Stem Cells.

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2014 New England User Group Meeting


Royal Sonesta, Boston
October 9, 2014
Cambridge, MA
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Vincent R. Zurawski, Jr., Ph.D. - President and Chief Executive Officer  - Hepregen
Title: Next Generation In Vitro Liver Testing Technology Transforming Drug Development Serving the Chemical and Cosmetics Industries

Dr. Eric Ballard - Principal Scientist - Pfizer
Title: Application of a micropatterned co-cultured (MPCC) hepatocyte system to predict preclinical and human specific drug metabolism.

Dr. Imad Hanna - Senior Senior Fellow - Novartis
Title: Studies with specialized human hepatocyte cultures to investigate drug metabolism/transport interplay

Vyas Ramanan - PhD Candidate - MIT
Title: Modeling hepatotropic infections in micropatterned cocultures

Dr. Keith Goodman - Senior Application Scientist - AB SCIEX
Title: The Chase is Started: HepatoPac® Co-Culture System Can Generate the Major Circulating and Excretory Human Metabolites of Loratadine and Desloratadine

Johnny Cardenas - Director of Business Development - AB SCIEX
Title: Metabolite Identification at your Fingertips - AB SCIEX Tools and Solutions for Accurate ID and Quant

Dr. Onyi Irrechukwu - Scientist I - Hepregen
Title: HepatoMune™: An in vitro platform for studying inflammation-drug interactions

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Mid-Atlantic User Group Meeting

Mid Atlantic User Group Meeting Mid-Atlantic User Group Meeting
May 21, 2014
West Conshohocken, PA


Dr. Salman Khetani - Colorado State University
Title: The Micropatterned Co-culture Platform: Past, Present and the Future

Dr. Tom Chan - Boehringer Ingelheim
Title: Leveraging longevity and high functionality of HepatoPac™ to derive clearance predictions for low clearance compounds

Dr. Ragu Ramanathan - Pfizer
Title: The Chase is Over: HepatoPac™ Co-Culture System Can Generate the Major Circulating and Excretory Human Metabolites of Loratadine and Desloratadine

Dr. William DeMaio - Ricerca
Title: Metabolism of Eight Model Pharmaceutical Compounds in Rat and Human HepatoPac™ versus Liver Microsomes and Suspension Hepatocytes Platforms

Dr. Imad Hanna - Novartis

Title: Studies with specialized human hepatocyte cultures to investigate drug metabolism/transport interplay

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Second Annual User Group Meeting

Second Annual User Group Meeting Second Annual Hepregen User Group Meeting
October 29, 2013
Royal Sonesta Hotel
Cambridge, MA


Edward LeCluyse, Senior Research Investigator - Institute for Chemical Safety Sciences  - The Hamner Institutes for Health Science
Title: Future Directions of In vitro Safety Testing: A Multi-phased Evaluation and Validation Study Using Micropatterned Co-cultures of Rat and Human Hepatocytes

Ragu Ramanathan, Ph.D., Director of Biotransformation and Bioanalytical DMPK  - QPS
Title: Minimizing Late Stage Human Specific Metabolite Surprises with HepatoPac™ Cultures: The Loratadine Story

Julius O. Enoru, Ph.D. and William DeMaio, Ph.D. - Ricerca
Title: Comparative Metabolism of Eight Model Pharmaceutical Compounds in Rat and Human - Liver Microsomes, Suspension Hepatocytes and the Hepregen HepatoPac™ Micropatterned Co-culture Platform

Yvonne Aratyn-Schaus, Ph.D., Product Development Scientist II  - Hepregen
Title: Characterization of Phase I and Phase II Drug Metabolism in Human, Rat, and Monkey HepatoPac™

Kenneth Brouwer, Ph.D., RPh., Chief Scientific Officer  - Qualyst Transporter Solutions
Title: Application of Whole Hepatocyte Systems for Predicting In Vivo Relevant Drug Interactions

David Peters, Sc.D., Senior Scientist, Discovery Toxicology  - Biogen
Title: In vitro Evaluation of the Toxicity Profiles of Selected Biogen Idec Compounds in Rat Hepatopac™ Co-Culture


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First Annual User Group Meeting

First Annual User Group Meeting Hepregen User Group Meeting
Friday, November 30, 2012
Hotel Marlowe
Cambridge, MA



Diane Ramsden - Boehringer-Ingelheim Pharmaceuticals, Inc.
Title: Bridging In Vitro and In Vivo Metabolism: Applications of HepatoPac™ 

Salman Khetani - Colorado State University
Title: The Use of HepatoPac™ to Detect Compounds that Cause Drug Induced Liver Injury in Humans

Sangeeta Bhatia - MIT
Title: The History of HepatoPac™ Microliver Technology

Scott Obach - Pfizer
Title: Use of Micropatterned Human Hepatocyte System for ADME Research


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