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Exploring Interactions Between Rat Hepatocytes and Nonparenchymal Cells Using Gene Expression Profiling

Co-cultivation of primary hepatocytes with a plethora of nonparenchymal cells (from within and outside the liver) has been shown to support hepatic functions in vitro. Despite significant investigation into this phenomenon, the molecular mechanism underlying epithelial–nonparenchymal interactions in hepatocyte cocultures remains poorly understood. In this publication, the authors present a functional genomic approach utilizing gene expression profiling to isolate molecular mediators potentially involved in induction of liver-specific functions by nonparenchymal cells.

 

Exploring Interactions Between Rat Hepatocytes Publication