Induction Studies

The induction or inhibition of CYP450 enzymes can be an important aspect of clinical drug-drug interactions. HepatoPac® can be a valuable platform for the study of CYP450 enzyme induction. Because of HepatoPac's extended longevity, it is the ideal platform to investigate long-term induction or inhibition.

 


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Prolonged chemical induction of hepatocyte CYP3A4 activity over 7 days.

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Chemical induction of CYP3A4, CYP2C9, and CYP1A2 at culture day 11.