Membrane transporters can have important effects on pharmacokinetics and drug exposure as mentioned in the FDA's Guidance for Industry on Drug Interaction Studies*. HepatoPac®'s improved functionality and longevity have made it a valuable tool in assessing transporter-mediated uptake and efflux.
HepatoPac expresses most drug transporters and exhibits higher levels of transporter-mediated compound uptake compared to sandwich cultures. Furthermore, HepatoPac retains optimal transporter functions for several weeks compared to days in sandwich cultures. As a result of microengineering, the HepatoPac cellular architecture creates a highly reproducible in vitro model exhibiting a consistent and extensive bile canalicular network.
Click below to learn about our transporter kit, developed with Qualyst Transporter Solutions.
Studies with specialized human hepatocyte cultures to investigate drug metabolism/transport interplay - Request Presentation